Figure 5
From: Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility
Selectivity of the CID755673 analogs. Inhibition of PKCα (A), PKCβI (B), PKCδ (C), or CAMKIIα (D) by each of the 5 analogs was determined at 100 nM, 1 μM, and 10 μM concentrations. In the PKC assays, the potent PKC inhibitor GF109203X was used as a control. Data are the mean ± S.E.M. of three independent experiments. Statistical significance was determined using the unpaired t-test. ns, not statistically significant; *, p < 0.05; **, p < 0.01; ***, p < 0.001.