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  1. Research article

    The effect of amino acid deletions and substitutions in the longest loop of GFP

    The effect of single and multiple amino acid substitutions in the green fluorescent protein (GFP) from Aequorea victoria has been extensively explored, yielding several proteins of diverse spectral properties. Ho...

    Gabriela Flores-Ramírez, Manuel Rivera, Alfredo Morales-Pablos, Joel Osuna, Xavier Soberón and Paul Gaytán

    BMC Chemical Biology 2007 7:1

    Published on: 26 June 2007

  2. Research article

    Studies on the synthesis, characterization, binding with DNA and activities of two cis-planaramineplatinum(II) complexes of the form: cis-PtL(NH3)Cl2 where L = 3-hydroxypyridine and 2,3-diaminopyridine

    Cis-planaramineplatinum(II) complexes like their trans isomers are often found to be active against cancer cell lines. The present study deals with the synthesis, characterization and determination of activity of...

    Ahmed Abdullah, Fazlul Huq, Ashraf Chowdhury, Hasan Tayyem, Philip Beale and Keith Fisher

    BMC Chemical Biology 2006 6:3

    Published on: 13 March 2006

  3. Research article

    Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator

    Urokinase-type plasminogen activator (uPA) plays a major role in extracellular proteolytic events associated with tumor cell growth, migration and angiogenesis. Consequently, uPA is an attractive target for th...

    Justin J Heynekamp, Lucy A Hunsaker, Thomas A Vander Jagt, Lorraine M Deck and David L Vander Jagt

    BMC Chemical Biology 2006 6:1

    Published on: 8 February 2006

  4. Research article

    An informatics search for the low-molecular weight chromium-binding peptide

    The amino acid composition of a low molecular weight chromium binding peptide (LMWCr), isolated from bovine liver, is reportedly E:G:C:D::4:2:2:2, though its sequence has not been discovered. There is some con...

    Deendayal Dinakarpandian, Vincent Morrissette, Shveta Chaudhary, Kambiz Amini, Brian Bennett and J David Van Horn

    BMC Chemical Biology 2004 4:2

    Published on: 16 December 2004

  5. Research article

    Synthesis and cytotoxicity of a biotinylated CC-1065 analogue

    The use of pretargeting technology for cancer imaging and treatment has made significant progress in the last few years. This approach takes advantage of the fact that biotin binds strongly to proteins avidin ...

    Yuqiang Wang, Huiling Yuan, Susan C Wright, Hong Wang and James W Larrick

    BMC Chemical Biology 2002 2:1

    Published on: 28 January 2002

  6. Research article

    Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the α-β bridging oxygen and β phosphorus replacement

    The human FHIT gene is inactivated early in the development of many human cancers and loss of Fhit in mouse predisposes to cancer while reintroduction of FHIT suppresses tumor formation via induction of apoptosis...

    James M Varnum, Janina Baraniak, Renata Kaczmarek, Wojciech J Stec and Charles Brenner

    BMC Chemical Biology 2001 1:3

    Published on: 16 October 2001

  7. Research article

    Calculated conformer energies for organic molecules with multiple polar functionalities are method dependent: Taxol (case study)

    Molecular mechanics (MM) and quantum chemical (QM) calculations are widely applied and powerful tools for the stereochemical and conformational investigations of molecules. The same methods have been extensive...

    Ami Lakdawala, Minmin Wang, Neysa Nevins, Dennis C Liotta, Danuta Rusinska-Roszak, Marek Lozynski and James P Snyder

    BMC Chemical Biology 2001 1:2

    Published on: 1 October 2001

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