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  1. Research article

    Anti-cancer activity of novel dibenzo[b,f]azepine tethered isoxazoline derivatives

    Dibenzoazepine (DB) derivatives are important and valuable compounds in medicinal chemistry. The synthesis and chemotherapeutic properties of naturally occurring DBs and different heterocyclic moiety tethered ...

    Maralinganadoddi Panchegowda Sadashiva, Basappa, Shivananju NanjundaSwamy, Feng Li, Kanjoormana Aryan Manu, Murugan Sengottuvelan, Doddakunche Shivaramu Prasanna, Nirvanappa Chikkagundagal Anilkumar, Gautam Sethi, Kazuyuki Sugahara and Kanchugarakoppal Subbegowda Rangappa

    BMC Chemical Biology 2012 12:5

    Published on: 3 October 2012

  2. Research article

    High toxicity and specificity of the saponin 3-GlcA-28-AraRhaxyl-medicagenate, from Medicago truncatula seeds, for Sitophilus oryzae

    Because of the increasingly concern of consumers and public policy about problems for environment and for public health due to chemical pesticides, the search for molecules more safe is currently of great impo...

    Pedro Da Silva, Vanessa Eyraud, Maïté Carre-Pierrat, Catherine Sivignon, Isabelle Rahioui, Corinne Royer and Frédéric Gressent

    BMC Chemical Biology 2012 12:3

    Published on: 2 July 2012

  3. Methodology article

    Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental verifications

    Identification of the target proteins of bioactive compounds is critical for elucidating the mode of action; however, target identification has been difficult in general, mostly due to the low sensitivity of d...

    Hiroki Kobayashi, Hiroko Harada, Masaomi Nakamura, Yushi Futamura, Akihiro Ito, Minoru Yoshida, Shun-ichiro Iemura, Kazuo Shin-ya, Takayuki Doi, Takashi Takahashi, Tohru Natsume, Masaya Imoto and Yasubumi Sakakibara

    BMC Chemical Biology 2012 12:2

    Published on: 5 April 2012

  4. Research article

    HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck

    Nef is an HIV-1 accessory protein essential for viral replication and AIDS progression. Nef interacts with a multitude of host cell signaling partners, including members of the Src kinase family. Nef preferent...

    Teodora Pene-Dumitrescu, Sherry T Shu, Thomas E Wales, John J Alvarado, Haibin Shi, Purushottam Narute, Jamie A Moroco, Joanne I Yeh, John R Engen and Thomas E Smithgall

    BMC Chemical Biology 2012 12:1

    Published on: 15 March 2012

  5. Research article

    Chemical modification of L-glutamine to alpha-amino glutarimide on autoclaving facilitates Agrobacterium infection of host and non-host plants: A new use of a known compound

    Accidental autoclaving of L-glutamine was found to facilitate the Agrobacterium infection of a non host plant like tea in an earlier study. In the present communication, we elucidate the structural changes in L-g...

    Indra Sandal, Amita Bhattacharya, Uksha Saini, Devinder Kaur, Shveta Sharma, Ashu Gulati, Jonnala K Kumar, Neeraj Kumar, Jyotsna Dayma, Pralay Das, Bikram Singh and Paramvir S Ahuja

    BMC Chemical Biology 2011 11:1

    Published on: 31 May 2011

  6. Research article

    Chemical-genetic profile analysis of five inhibitory compounds in yeast

    Chemical-genetic profiling of inhibitory compounds can lead to identification of their modes of action. These profiles can help elucidate the complex interactions between small bioactive compounds and the cell...

    Md Alamgir, Veronika Erukova, Matthew Jessulat, Ali Azizi and Ashkan Golshani

    BMC Chemical Biology 2010 10:6

    Published on: 6 August 2010

  7. Research article

    Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility

    Protein kinase D (PKD) has been implicated in a wide range of cellular processes and pathological conditions including cancer. However, targeting PKD therapeutically and dissecting PKD-mediated cellular respon...

    Courtney R LaValle, Karla Bravo-Altamirano, Karthik V Giridhar, Jun Chen, Elizabeth Sharlow, John S Lazo, Peter Wipf and Q Jane Wang

    BMC Chemical Biology 2010 10:5

    Published on: 5 May 2010

  8. Research article

    Dietary phenethylisothiocyanate attenuates bowel inflammation in mice

    Phenethylisothiocyanate (PEITC) is produced by Brassica food plants. PEO is a P EITC E ssential O il containing >95% natural PEITC. PEITC is known to produce various health benefits but its effect in alleviation ...

    Moul Dey, Peter Kuhn, David Ribnicky, VummidiGiridhar Premkumar, Kenneth Reuhl and Ilya Raskin

    BMC Chemical Biology 2010 10:4

    Published on: 27 April 2010

  9. Research article

    NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity

    NAD+ is a coenzyme for hydride transfer enzymes and a substrate for sirtuins and other NAD+-dependent ADPribose transfer enzymes. In wild-type Saccharomyces cerevisiae, calorie restriction accomplished by glucose...

    Charles Evans, Katrina L Bogan, Peng Song, Charles F Burant, Robert T Kennedy and Charles Brenner

    BMC Chemical Biology 2010 10:2

    Published on: 22 February 2010

  10. Research article

    Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1

    Disorazoles are polyene macrodiolides isolated from a myxobacterium fermentation broth. Disorazole C1 was newly synthesized and found to depolymerize microtubules and cause mitotic arrest. Here we examined the ce...

    Fengfeng L Xu, Youssef Rbaibi, Kirill Kiselyov, John S Lazo, Peter Wipf and William S Saunders

    BMC Chemical Biology 2010 10:1

    Published on: 11 February 2010

  11. Research article

    Glycosylated VCAM-1 isoforms revealed in 2D western blots of HUVECs treated with tumoral soluble factors of breast cancer cells

    Several common aspects of endothelial phenotype, such as the expression of cell adhesion molecules, are shared between metastasis and inflammation. Here, we analyzed VCAM-1 variants as biological markers of th...

    Delina Montes-Sánchez, Jose Luis Ventura, Irma Mitre, Susana Frías, Layla Michán, Aurora Espejel-Nuñez, Felipe Vadillo-Ortega and Alejandro Zentella

    BMC Chemical Biology 2009 9:7

    Published on: 22 November 2009

  12. Software

    DG-AMMOS: A New tool to generate 3D conformation of small molecules using D istance G eometry and A utomated M olecular M echanics O ptimization for in silico S creening

    Discovery of new bioactive molecules that could enter drug discovery programs or that could serve as chemical probes is a very complex and costly endeavor. Structure-based and ligand-based in silico screening app...

    David Lagorce, Tania Pencheva, Bruno O Villoutreix and Maria A Miteva

    BMC Chemical Biology 2009 9:6

    Published on: 13 November 2009

  13. Research article

    Local and global modes of drug action in biochemical networks

    It is becoming increasingly accepted that a shift is needed from the traditional target-based approach of drug development towards an integrated perspective of drug action in biochemical systems. To make this ...

    Jean-Marc Schwartz and Jose C Nacher

    BMC Chemical Biology 2009 9:4

    Published on: 7 April 2009

  14. Methodology article

    Chemical tools selectively target components of the PKA system

    In the eukaryotic cell the cAMP-dependent protein kinase (PKA) is a key enzyme in signal transduction and represents the main target of the second messenger cAMP. Here we describe the design, synthesis and cha...

    Daniela Bertinetti, Sonja Schweinsberg, Susanne E Hanke, Frank Schwede, Oliver Bertinetti, Stephan Drewianka, Hans-Gottfried Genieser and Friedrich W Herberg

    BMC Chemical Biology 2009 9:3

    Published on: 12 February 2009

  15. Research article

    Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus

    Hepatitis C virus (HCV) infection is a global health problem. A number of studies have implicated a direct role of cellular lipid metabolism in the HCV life cycle and inhibitors of the mevalonate pathway have ...

    John Paul Pezacki, Selena M Sagan, Angela M Tonary, Yanouchka Rouleau, Sylvie Bélanger, Lubica Supekova and Andrew I Su

    BMC Chemical Biology 2009 9:2

    Published on: 16 January 2009

  16. Research article

    Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue

    Topoisomerase II poisons are in clinical use as anti-cancer therapy for decades and work by stabilizing the enzyme-induced DNA breaks. In contrast, catalytic inhibitors block the enzyme before DNA scission. Al...

    Patrick Chène, Joëlle Rudloff, Joseph Schoepfer, Pascal Furet, Peter Meier, Zhiyan Qian, Jean-Marc Schlaeppi, Rita Schmitz and Thomas Radimerski

    BMC Chemical Biology 2009 9:1

    Published on: 7 January 2009

  17. Research article

    Chemogenetic fingerprinting by analysis of cellular growth dynamics

    A fundamental goal in chemical biology is the elucidation of on- and off-target effects of drugs and biocides. To this aim chemogenetic screens that quantify drug induced changes in cellular fitness, typically...

    Jonas Warringer, Dragi Anevski, Beidong Liu and Anders Blomberg

    BMC Chemical Biology 2008 8:3

    Published on: 22 August 2008

  18. Research article

    Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II

    Intracellular free calcium ([Ca2+]i) is a key element in apoptotic signaling and a number of calcium-dependent apoptosis pathways have been described. We here used a chemical biology strategy to elucidate the rel...

    Maria Hägg Olofsson, Aleksandra Mandic Havelka, Slavica Brnjic, Maria C Shoshan and Stig Linder

    BMC Chemical Biology 2008 8:2

    Published on: 1 August 2008

  19. Research article

    Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae

    Sortin2 is a low mass compound that interferes with vacuolar delivery of proteins in plants and yeast. The Sortin2 phenotype was tested in Arabidopsis thaliana and found to be reversible upon drug removal, demons...

    Lorena Norambuena, Jan Zouhar, Glenn R Hicks and Natasha V Raikhel

    BMC Chemical Biology 2008 8:1

    Published on: 7 January 2008

  20. Research article

    Enhancement of intracellular γ-tocopherol levels in cytokine-stimulated C3H 10T1/2 fibroblasts: relation to NO synthesis, isoprostane formation, and tocopherol oxidation

    Stimulation of C3H 10T1/2 murine fibroblasts with interferon-γ(IFN) and bacterial lipopolysaccharide (LPS) generates reactive oxygen and nitrogen species leading to DNA damage, lipid oxidation, and tocopherol ...

    Yuichiro Tanaka, Leslie A Lesoon Wood and Robert V Cooney

    BMC Chemical Biology 2007 7:2

    Published on: 3 July 2007

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