From: Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the α-β bridging oxygen and β phosphorus replacement
X = O
X = S
Comp.
R1
Ki (nM)
a
b
1
2600
-
2
3
86000
4
5
1500
220
6
4700
35