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Table 1 Fhit inhibition by AppppA analogs varied in interadenylate linker and phosphorothiolation.

From: Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the α-β bridging oxygen and β phosphorus replacement

    
   X = O X = S
Comp. R1 Ki (nM) Ki (nM)
   a b
1 2600 -
2 - 2600
3 - 86000
4 - 86000
5 1500 220
6 4700 35