BMC Chemical Biology

Table 1 Fhit inhibition by AppppA analogs varied in interadenylate linker and phosphorothiolation.

From: Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the α-β bridging oxygen and β phosphorus replacement


		X = O	X = S
Comp.	R1	K_i (nM)	K_i (nM)
		a	b
1		2600	-
2		-	2600
3		-	86000
4		-	86000
5		1500	220
6		4700	35

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