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Table 1 Cytotoxicity of compounds 1 and 2 against U937 leukemia cells in vitroa

From: Synthesis and preliminary cytotoxicity study of a cephalosporin-CC-1065 analogue prodrug

Compd. IC50 (nM)b
1 0.09
2 0.9
  1. aCells were incubated with drugs for 48 h and the experiments were performed according to our previously published method;27bIC50 values are defined as the minimal drug concentration necessary to inhibit incorporation of [3H]thymidine by 50%, and are the averages of three experiments.