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Table 3 Fold changes in gene expression in cells treated with triptolide (55.5 nM) as compared to endogenous expression levels in untreated cells.

From: MyD88-dependent and independent pathways of Toll-Like Receptors are engaged in biological activity of Triptolide in ligand-stimulated macrophages

a) Downregulation (≤-3) of LPS-non responsive genes by triptolide.
Gene symbol Accession No. Gene Name Fold change in response to triptolide
Bcl6 NM_009744 B-cell leukemia/lymphoma 6 -5.36
Cxcr3 NM_009910 Chemokine (C-X-C motif) receptor 3 -7.63
Tnfrsf1a NM_011609 Tumor necrosis factor receptor superfamily, member 1a -5.18
Eif2ak2 NM_011163 Eukaryotic translation initiation factor 2-alpha kinase 2 -4.51
Tlr3 NM_126166 Toll-like receptor 3 -10.73
Tlr7 NM_133211 Toll-like receptor 7 -12.85
Ly96 NM_016923 Lymphocyte antigen 96 -4.28
Map2k4 NM_009157 Mitogen activated protein kinase kinase 4 -3.01
b) Upregulation (≥+3) of LPS-non responsive genes by triptolide.
Gene symbol Accession No. Gene Name Fold change in response to triptolide
Ccl25 NM_009138 Chemokine (C-C motif) ligand 25 6.05
Fasl NM_010177 Fas ligand (TNF superfamily, member 6) 115.09
Irf1 NM_008390 Interferon regulatory factor 1 7.60
Mapk3 NM_011952 Mitogen activated protein kinase 3 5.84
Tnfsf14 NM_019418 Tumor necrosis factor (ligand) superfamily, member 14 17.71
Traf3 NM_011632 Tnf receptor-associated factor 3 3.38
  1. LPS (1 μg/ml) did not have any effect on these genes.