Table 3 Fold changes in gene expression in cells treated with triptolide (55.5 nM) as compared to endogenous expression levels in untreated cells.
a) Downregulation (≤-3) of LPS-non responsive genes by triptolide. | |||
|---|---|---|---|
Gene symbol | Accession No. | Gene Name | Fold change in response to triptolide |
Bcl6 | NM_009744 | B-cell leukemia/lymphoma 6 | -5.36 |
Cxcr3 | NM_009910 | Chemokine (C-X-C motif) receptor 3 | -7.63 |
Tnfrsf1a | NM_011609 | Tumor necrosis factor receptor superfamily, member 1a | -5.18 |
Eif2ak2 | NM_011163 | Eukaryotic translation initiation factor 2-alpha kinase 2 | -4.51 |
Tlr3 | NM_126166 | Toll-like receptor 3 | -10.73 |
Tlr7 | NM_133211 | Toll-like receptor 7 | -12.85 |
Ly96 | NM_016923 | Lymphocyte antigen 96 | -4.28 |
Map2k4 | NM_009157 | Mitogen activated protein kinase kinase 4 | -3.01 |
b) Upregulation (≥+3) of LPS-non responsive genes by triptolide. | |||
Gene symbol | Accession No. | Gene Name | Fold change in response to triptolide |
Ccl25 | NM_009138 | Chemokine (C-C motif) ligand 25 | 6.05 |
Fasl | NM_010177 | Fas ligand (TNF superfamily, member 6) | 115.09 |
Irf1 | NM_008390 | Interferon regulatory factor 1 | 7.60 |
Mapk3 | NM_011952 | Mitogen activated protein kinase 3 | 5.84 |
Tnfsf14 | NM_019418 | Tumor necrosis factor (ligand) superfamily, member 14 | 17.71 |
Traf3 | NM_011632 | Tnf receptor-associated factor 3 | 3.38 |