Figure 1

Effects of orally administered PEO and 5-ASA on the Disease activity index (DAI) in DSS-induced colitis. Experimental mouse groups and disease induction are defined in Table 1 and scoring criteria in Table 2. Significance of treatments in PEO and 5-ASA groups in respect to DSS group and are indicated by *, p < 0.05 and **p < 0.01 and ***p < 0.001. (A) Acute colitis model. Data as mean ± SEM (n = 6) are shown at five-day intervals. (B) Chronic colitis model. Data as mean ± SEM (n = 10) are shown at three-and two-day intervals during induction and treatment periods respectively.