Table 5 Genes down-regulated (≥ 3-fold vs LPS activation alone) by 10 μM PEO in macrophages
From: Dietary phenethylisothiocyanate attenuates bowel inflammation in mice
Gene name abbreviation | Gene name full | Partial Gene Ontology term | Fold change in response to LPS |
|---|---|---|---|
CCL2* | Chemokine (C-C motif) ligand 2 | Inflammatory response; Chemokine activity | -35.67 |
CSF2 | Colony stimulating factor 2 (granulocyte- macrophage) | Immune response; Cytokine and chemokine mediated signaling pathway | -8.21 |
CSF3 | Colony stimulating factor 3 (granulocyte) | Immune response; Cytokine activity | -53.69 |
CXCL10* | Chemokine (C-X-C motif) ligand 10 | Inflammatory response; Chemokine activity | -30.05 |
FOS | FBJ osteosarcoma oncogene | DNA binding; Regulation of transcription | -10.90 |
GJA1 | Gap junction membrane channel protein alpha 1 | Cell-cell signaling | -19.25 |
IL10 | Interleukin 10 | Immune response; Cytokine activity | -4.95 |
IL1a | Interleukin 1 alpha | Inflammatory response; Cytokine activity | -291.36 |
IL1b | Interleukin 1 beta | Inflammatory response; Cytokine activity; Neutrophil chemotaxis; Positive regulation of IL-6 and chemokine biosynthesis | -32.83 |
IL6* | Interleukin 6 | Signal transducer and cytokine activity | -14.39 |
MAPK3 | Mitogen activated protein kinase 3 | ATP binding; Transferase activity; Protein amino acid phosphorylation; Signal transduction; Inflammatory response; Regulation of cytokine biosynthesis; MAP kinase activity | -3.11 |
NFkB1 | Nuclear factor of kappa light chain gene enhancer in B-cells 1, p105 | DNA binding; Regulation of transcription | -21.51 |
NFkB2 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | DNA binding; Regulation of transcription | -5.72 |
NFkBia | Nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha | Nucleus; Protein binding; Cytoplasm: Regulation of cell proliferation; Protein-nucleus import, translocation | -8.21 |
REL | Reticuloendotheliosis oncogene | DNA binding; Regulation of transcription | -5.76 |
RELb | Avian reticuloendotheliosis viral (v-rel) oncogene related B | Transcription factor activity; Intracellular; T-helper 1 type immune response | -3.78 |
RIPK2 | Receptor (TNFRSF)-interacting serine-threonine kinase 2 | Regulation of apoptosis | -5.72 |
SLC20a1* | Solute carrier family 20, member 1 | Receptor activity; Phosphate transport | -6.81 |
STAT1* | Signal transducer and activator of transcription 1 | DNA binding; Regulation of transcription | -4.81 |
TNFaip3* | Tumor necrosis factor, alpha-induced protein 3 | Apoptosis; Zinc ion binding | -134.05 |
CD40* | CD40 antigen | Signal transduction; Immune response; Apoptosis | -46.74 |