Table 1 In vitro inhibitory activity of CID755673 and its analogs for PKD
From: Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility
IC 50 (nM) | |||
|---|---|---|---|
Compound | PKD1 | PKD2 | PKD3 |
CID755673 | 182 ± 27 (n = 5) | 280 ± 1.8 (n = 3) | 227 ± 24 (n = 3) |
Kb-NB142-70 | 28.3 ± 2.3 (n = 3) | 58.7 ± 4.2 (n = 3) | 53.2 ± 3.5 (n = 3) |
Kb-NB165-09 | 82.5 ± 4.6 (n = 4) | 141.6 ± 7.4 (n = 3) | 98.5 ± 15.3 (n = 3) |
Kb-NB165-31 | 114.1 ± 23.9 (n = 3) | 162.9 ± 20.5 (n = 3) | 91.1 ± 17.2 (n = 3) |
Kb-NB165-92 | 111.2 ± 6 (n = 3) | 100.7 ± 10.9 (n = 3) | 58.8 ± 7.3 (n = 3) |
Kb-NB184-02 | 192.8 ± 27.4 (n = 3) | 463.2 ± 38.2 (n = 4) | 324.7 ± 39.0 (n = 3) |