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Table 2 Cellular inhibition of PKD1 autophosphorylation at S916 by CID755673 analogs

From: Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility

Compound Cellular IC50 (μM)
kb-NB142-70 2.2 ± 0.6 (n = 3)
kb-NB165-09 3.1 ± 0.5 (n = 3)
kb-NB165-31 8.6 ± 2.0 (n = 3)
kb-NB165-92 2.6 ± 0.7 (n = 2)
kb-NB184-02 18.6 ± 2.0 (n = 3)
  1. Cellular IC50 was determined by densitometry analysis of Western blotting data for PKD1 autophosphorylation at S916 in LNCaP cells. Each IC50 was calculated as the mean ± S.E.M. of at least two independent experiments. *n, number of independent experiments