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Table 3 Kinase profiling report for CID755673

From: Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility

  CID755673, 10 μM   CID755673, 10 μM
Kinase Average % Inhibition Kinase Average % Inhibition
ABL 8 KDR 8
AKT1 3 MAPKAPK2 95
AKT2 4 MARK1 12
AMPK 35 MET 18
AurA 7 MSK1 7
BTK -3 p38a 2
CAMK4 17 p70S6K 44
CDK2 71 PAK2 3
CHK1 7 PDGFRα 5
CHK2 4 PDK1 22
CK1δ 82 PIM2 6
c-Raf 2 PKA 6
EGFR 11 PKCη 40
ErbB4 1 PKCγ 30
Erk1 50 PKCθ 32
Erk2 31 PKCζ -4
FGFR1 16 PKD2 95
FLT3 14 PKG1α 13
GSK3β 86 PKG1β 11
IGF1R -2 MK5/PRAK 75
Ikkb 49 RSK1 29
IBSR 3 SGK1 9
IRAK4 0 SRC 7
JNK2 36 SYK -8
  1. 48 kinases were interrogated using a single-dose in vitro kinase assay at 10 μM CID755673. -20 to +20% inhibition, baseline levels; >20 to 49% inhibition, compound only marginally actively inhibits the kinase; >50% inhibition, compound is actively inhibiting the kinase. The assay was performed by Caliper Life Sciences (Hanover, MD).