From: HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck
Condition | Km, ATP (μM) | IC50, NaPP1 (nM) |
---|---|---|
mHck alone | 12.1 ± 2.0 | > 1,000 |
mHck + Nef-SF2 | 14.8 ± 1.4 | > 1,000 |
mHck-TA alone | 62 ± 12.6 | 53.3 ± 8.2 |
mHck-TA + Nef-SF2 | 68 ± 10.7 | 47.4 ± 6.0 |
mHck-TA + Nef-Consensus | 84 ± 3.5 | 37.6 ± 4.6 |
mHck-HART alone | 105.2 ± 29.0 | n.d. |
mHck-HART + Nef-SF2 | 49.34 ± 5.8 | n.d. |
mHck-TA-HART alone | 181 ± 28.7 | 8.5 ± 0.7 |
mHck-TA-HART + Nef-SF2 | 69 ± 17.6 | 2.4 ± 0.3 |
mHck-TA-HART + Nef-Consensus | 76 ± 23.1 | 3.2 ± 0.2 |