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Table 1 Cytotoxicity of compounds 5, 6, and doxorubicin against U937 leukemia cells in vitroa

From: Synthesis and cytotoxicity of a biotinylated CC-1065 analogue

Compd. IC50 (nM)b
5 0.09
6 0.7
Doxorubicin 100
  1. aCells were incubated with drugs for 48 h and the experiments were performed according to our previously published method [26]; bIC50 values are defined as the minimal drug concentration necessary to inhibit incorporation of [3H]thymidine by 50%, and are the averages of three experiments.