Figure 2From: Redesigned and chemically-modified hammerhead ribozymes with improved activity and serum stabilityDegradation of 5' end-labelled Mrz-12/12 A in RPMI + 10% human serum at 37°C. Time of incubation in indicated above each lane. OH-indicates an alkaline digest of the same material. FL indicates the position of the full-length miniribozyme. The position of the fragments terminating at each of the ribonucleotides is indicated by the letters adjacent to the alkaline digest.Back to article page