Table 1 Dissociation constants for inhibition of human uPA
From: Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator
Structure | Number | Ki (μM) | Structure | Number | Ki (μM) |
|---|---|---|---|---|---|
| 4a | 1.8 ± 0.2 |
| 7a | 0.020 ± 0.003 |
| 4b | 2.4 ± 0.2 |
| 7b | 0.038 ± 0.005 |
| 4c | 14 ± 1 |
| 8a | 1.4 ± 0.2 |
| 4d | 9 ± 1 |
| 8b | 0.034 ± 0.002 |
| 4e | 18 ± 2 |
| 9a | 0.084 ± 0.007 |
| 5c | 0.033 ± 0.004 |
| 9b | 0.010 ± 0.008 |
| 5d | 0.055 ± 0.003 |
| 10a | 4.2 ± 0.4 |
| 5e | 0.14 ± 0.02 |
| 10b | 4.3 ± 0.3 |
| 6a | 12 ± 1 |
| 10c | 14 ± 2 |
| 6b | 9.5 ± 1 |
| 11 | 65 ± 9 |
