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Table 4 IC50 value and resistance factors for AH3, AH7 and cisplatin against the cell lines: A2780, A2780cisR and A2780ZD047R.

From: Studies on the synthesis, characterization, binding with DNA and activities of two cis-planaramineplatinum(II) complexes of the form: cis-PtL(NH3)Cl2 where L = 3-hydroxypyridine and 2,3-diaminopyridine

 

A2780

A2780-cisR

IC50A2780cisR/IC50A2780

A2780ZD0473R

 

IC50

IC50

RF

IC50

AH3

3.8 ± 1.0

6.9 ± 1.0

1.8

7.5 ± 1.0

AH7

11.7 ± 1.4

8.5 ± 1.3

0.7

10.6 ± 1.0

Cisplatin

1.1 ± 0.4

2.3 ± 0.4

2.1

2.2 ± 0.4

  1. The letters 's', 'm', 'w', 'd' and 'br' stand for 'strong', 'medium', 'weak', 'doublet' and 'broad' respectively.