Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae

Table 1 Functional and locational gene product categorization of Sortin2 hypersensitive ORFs.

	Representation on dataset			Enrichment on dataset (-fold)
	Sortin2	Genome	p-value
FUNCTIONAL CATEGORY
Cellular transport, transport facilities and transport routes	50.7	16.9	2.99 E-29	3.0
Protein fate (folding, modification, destination)	46.2	18.8	1.51 E-19	2.5
Biogenesis of cellular components	21.3	14	0.003	1.5
Interaction with the environment	12.9	7.55	0.004	1.7
LOCATIONAL CATEGORY
Endosome	16.4	0.94	6.2 E-35	17.5
Golgi	13.9	2.57	1.0 E-13	5.4
Transport vesicles	11.4	2.29	1.1 E-10	5.0
Punctate composite	8.95	2.29	6.3 E-07	3.9
Vacuole	16.4	4.63	1.1 E-10	3.5
ER	15.9	9.1	0.0011	1.8

Category representation of the abundance within Sortin2 hypersensitive (201 genes) and the Saccharomyces genome (6131 genes). P-value was calculated using hypergeometric distribution as statistical test. P-values < 0.0005 were considered as statistical significant.