Figure 2

Differential impact of bioactive compounds on cellular growth dynamics. A) Growth of yeast WT populations in the presence of increasing doses of bioactive compounds. Concentrations of NaCl (2 M, 1.5 M, 1.2 M, 0.9 M, 0.65 M, 0.45 M, 0.3 M, 0.2 M), Diamide (1.9 mM, 1.5 mM, 1.2 mM, 1 mM, 0.8 mM, 0.6 mM, 0.45 mM, 0.3 mM), Paraquat (10 mg/mL, 5 mg/mL, 2.5 mg/mL, 1.2 mg/mL, 0.6 mg/mL, 0.3 mg/mL, 0.2 mg/mL, 0.1 mg/mL) are represented with colours, red indicating the lowest concentration, blue indicating the highest concentration. B) Dose response correlations of yeast WT populations considering growth lag (green), growth rate (red) and growth efficiency (blue), n = 2. C-D) Comparing the relative effects (LEC) of bioactive compounds on yeast WT fitness variables. Color indicates specific functional groups (red = ergosterol biosynthesis inhibitors, green = DNA damaging agents, blue = heavy metals, orange = redox status distorters). For growth lags, a cut-off at a 24-fold increase has been applied. C) Growth lag vs. growth rate. D) Growth efficiency vs. growth rate.