Figure 4

Drug-drug interactions in different physiological windows. Interactions within a mini-array of multi-replicated (n = 50 for single compounds, n = 20 for compound combinations) bioactive compounds. A) Multiplicative model of synthetic chemical interactions. B) Overview of all drug-drug interactions. Dashed line indicates null interaction, i.e. 1:1 correlation between observed (LEC_xy) and expected (LEC_x + LEC_y) effects. C-E) Heatmap of drug-drug interactions depicted as observed (LEC_xy) – expected (LEC_x + LEC_y) effects. Red = alleviation, green = aggravation.