Table 1 Kinase selectivity profiling of QAP 1 in radiometric filter binding assays
Kinase | IC50 (μM) | Kinase | IC50 (μM) |
|---|---|---|---|
HER-1 | > 10 | FGFR3-K560E | > 10 |
KDR | > 10 | Axl | > 10 |
Flt-3 | > 10 | Fak | > 10 |
IGF-1R | > 10 | c-Abl | > 10 |
Tek | > 10 | c-Abl-T315I | > 10 |
c-Src | 1.7 ± 0.5 | PKA | > 10 |
c-Met | > 10 | CDK1/CycB | > 10 |
Ret | 1.35 ± 0.05 | PKB | > 10 |
Jak2 | > 10 | PDK1 | > 10 |
EphB4 | > 10 | BRAF-V600E | > 10 |