Table 1 GeneChip analysis of downregulated genes after 25-HC treatment of Huh-7 cells and Huh-7 cells bearing HCV subgenomic replicons.a
Descriptionb | Name | Accession # | Fold change 25-HC-treated | Fold change 25-HC-treated HCV replicon | |
|---|---|---|---|---|---|
1 | chromosome 14 clone BAC 507E23 map 14q24.3 | B-ATF | AC007182 | -4.1 | -6.4 |
2 | mRNA for cysteine protease | D55696.1 | -3.9 | --- | |
3 | RNA binding motif protein 5 | RBM5 | NM_005778.1 | -3.1 | --- |
4 | tetratricopeptide repeat domain 3 | TTC3 | AI652848 | -3.1 | --- |
5 | insulin induced gene 1 | INSIG1 | BE300521 | -2.8 | -2.9 |
BG292233 | -2.2 | -1.9 | |||
NM_005542.1 | -2.2 | -2 | |||
6 | SON DNA binding protein | SON | AA664291 | -2.4 | -2.4 |
7 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | HMGCS1 | NM_002130.1 | -2.4 | -2.4 |
8 | Similar to Nedd-4-like ubiquitin-protein ligase, clone MGC:2079 | BC000108.1 | -2.3 | --- | |
9 | hypothetical protein DJ328E19.C1.1 | DJ328E19.C1.1 | BE732345 | -2.3 | --- |
10 | Human DNA sequence from clone RP1-221C16 on chromosome 6 | AL353759 | -2.2 | --- | |
11 | low density lipoprotein receptor | LDLR | AI861942 | -2.1 | -3.3 |
12 | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | HMGCR | AL518627 | -2.1 | -1.9 |
13 | fatty acid desaturase 1 | FADS1 | BG165833 | -2.1 | -1.7 |
14 | sterol-C5-desaturase homolog | D85181.1 | -2.1 | --- | |
15 | Human lanosterol 14-alpha demethylase | CYP51P2 | U40053 | -2.1 | -2 |
16 | FK506-binding protein 2 | FKBP2 | NM_004470.1 | -2 | -1.6 |
17 | apolipoprotein AI regulatory protein | ARP-1 | M64497.1 | -2 | -3.5 |
18 | Homo sapiens HDCMC28P protein | HDCMC28P | NM_016649.1 | -2 | --- |
19 | pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 1 | PLEKHA1 | NM_021622.1 | -2 | --- |
20 | olfactory receptor, family 7, subfamily A, member 17 | OR7A17 | NM_030901.1 | -1.9 | 2.4 |
21 | sterol-C4-methyl oxidase-like | SC4MOL | AV704962 | -1.9 | -2.5 |
22 | PRO0998 | PRO0998 | AF116616.1 | -1.9 | -2.6 |
23 | ASMneg1-b1 immunoglobulin lambda chain VJ region | IGL | AF043584.1 | -1.9 | 1.7 |
24 | bone marrow protein BM037 | BM037 | NM_018454.1 | -1.9 | --- |
25 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 | HMGCS1 | BG035985 | -1.9 | -2.6 |
26 | farnesyl diphosphate synthase | FDPS | NM_002004.1 | -1.8 | -1.8 |
27 | mevalonate (diphospho) decarboxylase | MVD | AI189359 | -1.8 | -3.1 |
28 | kinesin family member 3C | KIF3C | NM_002254.1 | -1.8 | --- |
29 | peptidyl-prolyl isomerase G (cyclophilin G) | PPIG | AW340788 | -1.8 | --- |
30 | acetyl-Coenzyme A acetyltransferase 2 | BC000408.1 | -1.8 | -1.6 | |
31 | farnesyl-diphosphate farnesyltransferase 1 | BC003573.1 | -1.8 | -2 | |
32 | Homo sapiens Kruppel-like factor | LOC51713 | NM_016270.1 | -1.8 | -2.4 |
33 | prospero-related homeobox 1 | PROX1 | NM_002763.1 | -1.7 | --- |
34 | cDNA FLJ13484 fis, clone PLACE1003888 | AK023546.1 | -1.7 | --- | |
35 | M10098 Human 18S rRNA sequence | -1.7 | --- | ||
36 | chromodomain helicase DNA binding protein 4 | CHD4 | AI761771 | -1.6 | -2.1 |
37 | topoisomerase (DNA) II alpha 170kDa | TOP2A | AU159942 | -1.6 | --- |
38 | 7-dehydrocholesterol reductase | DHCR7 | AW150953 | -1.6 | -2.2 |
39 | vesicle docking protein p115 | VDP | BE875592 | -1.6 | -1.5 |
40 | v-crk avian sarcoma virus CT10 oncogene homolog | CRK | NM_016823.1 | -1.6 | 1.7 |
41 | Nijmegen breakage syndrome 1 (nibrin) | NBS1 | AI796269 | -1.6 | --- |
42 | farnesyl-diphosphate farnesyltransferase 1 | FDFT1 | AA872727 | -1.6 | -2.2 |
43 | cDNA FLJ11371 fis, clone HEMBA1000356 | AK021433.1 | -1.6 | --- | |
44 | PAC clone RP5-979P20 from 7 | NPM1P12 | AC004941 | -1.6 | -1.5 |
45 | erythrocyte membrane protein band 4.1-like 2 | EPB41L2 | BF511685 | -1.5 | 1.9 |
46 | activated leukocyte cell adhesion molecule | ALCAM | BF242905 | -1.5 | -1.7 |
47 | protein kinase related to S. cerevisiae STE20 | PAK4 | NM_005884.2 | -1.5 | --- |
48 | cDNA: FLJ21342 fis, clone COL02673. | AK024995.1 | -1.5 | --- |