Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners

BMC Chemical Biology

Table 2 Representative Gene Ontology terms significantly enriched in target proteins.^a

GO-ID	Category Description	Corrected p-value	Number of target proteins selected	Total number of proteins in category	Fraction of population as targets
	Molecular Function
3824	catalytic activity	1.45E-19	115	5085	0.023
16491	oxidoreductase activity	2.76E-12	40	916	0.044
16209	antioxidant activity	2.93E-09	11	57	0.193
51920	peroxiredoxin activity	9.34E-08	5	6	0.833
16684	oxidoreductase activity, acting on peroxide as acceptor	5.71E-07	8	40	0.20
4364	glutathione transferase activity	3.30E-06	7	34	0.206
9031	thioredoxin peroxidase activity	3.30E-06	4	5	0.8
51082	unfolded protein binding	9.02E-05	9	115	0.078
5504	fatty acid binding	9.42E-04	5	37	0.135
	Biological Process
19752	carboxylic acid metabolic process	1.10E-14	35	524	0.067
6519	amino acid and derivative metabolic process	1.02E-08	23	362	0.064
9308	amine metabolic process	1.53E-08	24	414	0.058
6950	response to stress	4.82E-08	36	978	0.0369
6805	xenobiotic metabolic process	2.31E-07	8	32	0.25
9410	response to xenobiotic stimulus	2.74E-07	8	33	0.242
6979	response to oxidative stress	4.38E-07	12	110	0.109
6457	protein folding	1.28E-06	15	207	0.072
	Cellular Component
5737	cytoplasm	4.59E-26	108	3936	0.027
44444	cytoplasmic part	3.71E-23	91	2969	0.031
5739	mitochondrion	2.31E-16	41	750	0.055
5788	endoplasmic reticulum lumen	4.95E-10	8	20	0.4
5829	cytosol	2.95E-09	25	494	0.051
5783	endoplasmic reticulum	9.68E-09	25	525	0.048
5793	ER-Golgi intermediate compartment	2.07E-06	6	23	0.261
5625	soluble fraction	2.56E-06	15	260	0.058

^a GO analysis was performed using BinGO in Cytoscape. The rat proteome was used as the background for comparison. A complete listing of terms having a false discovery rate (FDR) < 1.0E-03 is presented in Table S3 (see Additional file 5). Also available in the Additional files are graphic representations of enriched GO categories and their hierarchical structures (Figures S1 and S2 in Additional files 1 and 2, respectively).