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Table 3 KEGG pathways significantly enriched in target proteins.a

From: Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners

Pathway Name Corrected p-value Number of target proteins selected Total number of proteins in pathway Fraction of population as targets
Glycolysis/Gluconeogenesis 2.96E-08 12 45 0.267
Glutathione metabolism 1.25E-06 9 30 0.300
Carbon fixation 9.92E-06 7 19 0.368
Pyruvate metabolism 1.25E-05 8 29 0.276
Urea cycle and metabolism of amino groups 1.38E-05 7 20 0.350
Arginine and proline metabolism 5.63E-05 7 25 0.280
Metabolism of xenobiotics by cytochrome P450 7.13E-05 9 50 0.180
Limonene and pinene degradation 2.70E-04 5 12 0.417
Propanoate metabolism 4.02E-04 6 23 0.261
Glutamate metabolism 4.97E-04 6 24 0.250
Phenylalanine metabolism 6.97E-04 5 15 0.333
3-Chloroacrylic acid degradation 7.50E-04 4 7 0.571
Fatty acid metabolism 8.59E-04 7 40 0.175
Nitrogen metabolism 9.09E-04 5 16 0.313
Cysteine metabolism 9.09E-04 5 16 0.313
  1. aPathway mapping was performed using DAVID, and 101 of 171 target proteins could be mapped to one or more KEGG pathways. The subset of rat proteins that are allocable to KEGG pathways includes 3396 proteins.
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BMC Chemical Biology

ISSN: 1472-6769