Skip to main content

Table 4 Summary of interacting partner analysis for human orthologs of 28 rat or mouse proteins commonly targeted by multiple different reactive metabolites a

From: Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners

Entrez id

Gene symbol

Human Protein name

Number of interacting partner proteins found

213

ALB

Albumin

12

217

ALDH2

Aldehyde dehydrogenase 2

7

383

ARG1

Arginase

2

761

CA3

Carbonic anhydrase III

3

2023

ENO1

Enolase 1

6

2168

FABP1

Fatty acid binding protein 1

2

2923

PDIA3

Protein disulfide isomerase A3

11

2944

GSTM1

Glutathione S-transferase Mu-1

4

2946

GSTM2

Glutathione S-transferase Mu-2

4

3309

HSPA5

BIP

31

3312

HSPA8

Heat shock 70 kDa protein 8

43

3417

IDH1

Isocitrate dehydrogenase 1

1

5034

P4HB

Protein disulfide isomerase

15

5037

PEBP1

Raf kinase inhibitor protein

18

5230

PGK1

Phosphoglycerate kinase 1

4

7170

TPM3

Tropomyosin 3

13

7276

TTR

Transthyretin

14

7295

TXN

Thioredoxin

10

8991

SELENBP1

Selenium binding protein 1

4

10130

PDIA6

Protein disulfide isomerase P5

2

10961

ERP29

Endoplasmic reticulum protein 29

4

1109

AKR1C4

Aldo keto reductase family 1, member C4

0

1652

DDT

D-dopachrome tautomerase

0

2052

EPHX1

Epoxide hydrolase

0

2184

FAH

Fumarylacetoacetase

0

2593

GAMT

Guanidinoacetate N-methyltransferase

0

10247

HRSP12

Translational inhibitor protein p14.5

0

51733

UPB1

Beta ureidopropionase

0

  1. a No interacting partners were found for 7 of the 28 proteins. See Additional file 5 for full listing of all the interacting partners found.