Table 1 Multiple sequence alignment showing conservation of the EDGEECDCGE motif in all known mammalian forms of ADAM19 and a homologous putative ADAM in fission yeast (top). Multiple sequence alignment showing proposed Cr(III) binding sequence, NKDDNEECGD, conserved in the insulin receptor (INSR) across species, but not in the insulin-like growth factor receptor (IG1R) (bottom).
From: An informatics search for the low-molecular weight chromium-binding peptide
SwissProt | Protein | Species | Sequence |
|---|---|---|---|
Q9H013 | ADAM19 | Human | GNGYLEDGEECDCGEEEE CNNP |
O35674 | ADAM19 | Mouse | GNGYLEDGEECDCGEEEE CNNP |
ADAM19 | Rat | GNGYLEDGEECDCGEEDE CKNP | |
O13766 | Homolog | S. Pombe | GNGIVEDGEECDCGEDCE NNPC |
P15208 | INSR | Mouse | NKDDNEECGD VCPGT |
P15127 | INSR | Rat | NKDDNEECGD VCPGT |
P06213 | INSR | Human | NKDDNEECGD ICPGT |
Q9PVZ4 | Homolog | Xenopus | NRDNKEECGD VCPGT |
Q60751 | IG1R | Mouse | NKPPKECGDLCPGTL |
P24062 | IG1R | Rat | NKPPKECGDLCPGTL |
P08069 | IG1R | Human | NKPPKECGDLCPGTL |
O73798 | Homolog | Xenopus | NKPPKECVDLCPGA. |