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  1. Content type: Research article

    Dibenzoazepine (DB) derivatives are important and valuable compounds in medicinal chemistry. The synthesis and chemotherapeutic properties of naturally occurring DBs and different heterocyclic moiety tethered ...

    Authors: Maralinganadoddi Panchegowda Sadashiva, Basappa, Shivananju NanjundaSwamy, Feng Li, Kanjoormana Aryan Manu, Murugan Sengottuvelan, Doddakunche Shivaramu Prasanna, Nirvanappa Chikkagundagal Anilkumar, Gautam Sethi, Kazuyuki Sugahara and Kanchugarakoppal Subbegowda Rangappa

    Citation: BMC Chemical Biology 2012 12:5

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  2. Content type: Research article

    Because of the increasingly concern of consumers and public policy about problems for environment and for public health due to chemical pesticides, the search for molecules more safe is currently of great impo...

    Authors: Pedro Da Silva, Vanessa Eyraud, Maïté Carre-Pierrat, Catherine Sivignon, Isabelle Rahioui, Corinne Royer and Frédéric Gressent

    Citation: BMC Chemical Biology 2012 12:3

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  3. Content type: Research article

    Wnt/β-catenin-mediated gene transcription plays important roles in a wide range of biological and pathophysiological processes including tumorigenesis where β-catenin-mediated transcription activity frequently...

    Authors: Tong Shi, Ju Bao, Nick X Wang, Jie Zheng and Dianqing Wu

    Citation: BMC Chemical Biology 2012 12:4

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  4. Content type: Methodology article

    Identification of the target proteins of bioactive compounds is critical for elucidating the mode of action; however, target identification has been difficult in general, mostly due to the low sensitivity of d...

    Authors: Hiroki Kobayashi, Hiroko Harada, Masaomi Nakamura, Yushi Futamura, Akihiro Ito, Minoru Yoshida, Shun-ichiro Iemura, Kazuo Shin-ya, Takayuki Doi, Takashi Takahashi, Tohru Natsume, Masaya Imoto and Yasubumi Sakakibara

    Citation: BMC Chemical Biology 2012 12:2

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  5. Content type: Research article

    Nef is an HIV-1 accessory protein essential for viral replication and AIDS progression. Nef interacts with a multitude of host cell signaling partners, including members of the Src kinase family. Nef preferent...

    Authors: Teodora Pene-Dumitrescu, Sherry T Shu, Thomas E Wales, John J Alvarado, Haibin Shi, Purushottam Narute, Jamie A Moroco, Joanne I Yeh, John R Engen and Thomas E Smithgall

    Citation: BMC Chemical Biology 2012 12:1

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  6. Content type: Methodology article

    Pentachloronitrobenzene (PCNB) and hexachlorobenzene (HCB) are highly toxic and widespread in every environmental compartment. Some of metabolic products such as amino/nitro containing chlorinated aromatic com...

    Authors: Fazlurrahman Khan, Dhan Prakash and RK Jain

    Citation: BMC Chemical Biology 2011 11:2

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  7. Content type: Research article

    Accidental autoclaving of L-glutamine was found to facilitate the Agrobacterium infection of a non host plant like tea in an earlier study. In the present communication, we elucidate the structural changes in L-g...

    Authors: Indra Sandal, Amita Bhattacharya, Uksha Saini, Devinder Kaur, Shveta Sharma, Ashu Gulati, Jonnala K Kumar, Neeraj Kumar, Jyotsna Dayma, Pralay Das, Bikram Singh and Paramvir S Ahuja

    Citation: BMC Chemical Biology 2011 11:1

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  8. Content type: Research article

    Chemical-genetic profiling of inhibitory compounds can lead to identification of their modes of action. These profiles can help elucidate the complex interactions between small bioactive compounds and the cell...

    Authors: Md Alamgir, Veronika Erukova, Matthew Jessulat, Ali Azizi and Ashkan Golshani

    Citation: BMC Chemical Biology 2010 10:6

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  9. Content type: Research article

    Protein kinase D (PKD) has been implicated in a wide range of cellular processes and pathological conditions including cancer. However, targeting PKD therapeutically and dissecting PKD-mediated cellular respon...

    Authors: Courtney R LaValle, Karla Bravo-Altamirano, Karthik V Giridhar, Jun Chen, Elizabeth Sharlow, John S Lazo, Peter Wipf and Q Jane Wang

    Citation: BMC Chemical Biology 2010 10:5

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  10. Content type: Research article

    Phenethylisothiocyanate (PEITC) is produced by Brassica food plants. PEO is a P EITC E ssential O il containing >95% natural PEITC. PEITC is known to produce various health benefits but its effect in alleviation ...

    Authors: Moul Dey, Peter Kuhn, David Ribnicky, VummidiGiridhar Premkumar, Kenneth Reuhl and Ilya Raskin

    Citation: BMC Chemical Biology 2010 10:4

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  11. Content type: Research article

    Triptolide is a diterpene triepoxide from the Chinese medicinal plant Tripterygium wilfordii Hook F., with known anti-inflammatory, immunosuppressive and anti-cancer properties.

    Authors: Vummidigiridhar Premkumar, Moul Dey, Ruth Dorn and Ilya Raskin

    Citation: BMC Chemical Biology 2010 10:3

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  12. Content type: Research article

    NAD+ is a coenzyme for hydride transfer enzymes and a substrate for sirtuins and other NAD+-dependent ADPribose transfer enzymes. In wild-type Saccharomyces cerevisiae, calorie restriction accomplished by glucose...

    Authors: Charles Evans, Katrina L Bogan, Peng Song, Charles F Burant, Robert T Kennedy and Charles Brenner

    Citation: BMC Chemical Biology 2010 10:2

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  13. Content type: Research article

    Disorazoles are polyene macrodiolides isolated from a myxobacterium fermentation broth. Disorazole C1 was newly synthesized and found to depolymerize microtubules and cause mitotic arrest. Here we examined the ce...

    Authors: Fengfeng L Xu, Youssef Rbaibi, Kirill Kiselyov, John S Lazo, Peter Wipf and William S Saunders

    Citation: BMC Chemical Biology 2010 10:1

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  14. Content type: Research article

    Several common aspects of endothelial phenotype, such as the expression of cell adhesion molecules, are shared between metastasis and inflammation. Here, we analyzed VCAM-1 variants as biological markers of th...

    Authors: Delina Montes-Sánchez, Jose Luis Ventura, Irma Mitre, Susana Frías, Layla Michán, Aurora Espejel-Nuñez, Felipe Vadillo-Ortega and Alejandro Zentella

    Citation: BMC Chemical Biology 2009 9:7

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  15. Content type: Software

    Discovery of new bioactive molecules that could enter drug discovery programs or that could serve as chemical probes is a very complex and costly endeavor. Structure-based and ligand-based in silico screening app...

    Authors: David Lagorce, Tania Pencheva, Bruno O Villoutreix and Maria A Miteva

    Citation: BMC Chemical Biology 2009 9:6

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  16. Content type: Research article

    It is becoming increasingly accepted that a shift is needed from the traditional target-based approach of drug development towards an integrated perspective of drug action in biochemical systems. To make this ...

    Authors: Jean-Marc Schwartz and Jose C Nacher

    Citation: BMC Chemical Biology 2009 9:4

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  17. Content type: Methodology article

    In the eukaryotic cell the cAMP-dependent protein kinase (PKA) is a key enzyme in signal transduction and represents the main target of the second messenger cAMP. Here we describe the design, synthesis and cha...

    Authors: Daniela Bertinetti, Sonja Schweinsberg, Susanne E Hanke, Frank Schwede, Oliver Bertinetti, Stephan Drewianka, Hans-Gottfried Genieser and Friedrich W Herberg

    Citation: BMC Chemical Biology 2009 9:3

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  18. Content type: Research article

    Hepatitis C virus (HCV) infection is a global health problem. A number of studies have implicated a direct role of cellular lipid metabolism in the HCV life cycle and inhibitors of the mevalonate pathway have ...

    Authors: John Paul Pezacki, Selena M Sagan, Angela M Tonary, Yanouchka Rouleau, Sylvie Bélanger, Lubica Supekova and Andrew I Su

    Citation: BMC Chemical Biology 2009 9:2

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  19. Content type: Research article

    Topoisomerase II poisons are in clinical use as anti-cancer therapy for decades and work by stabilizing the enzyme-induced DNA breaks. In contrast, catalytic inhibitors block the enzyme before DNA scission. Al...

    Authors: Patrick Chène, Joëlle Rudloff, Joseph Schoepfer, Pascal Furet, Peter Meier, Zhiyan Qian, Jean-Marc Schlaeppi, Rita Schmitz and Thomas Radimerski

    Citation: BMC Chemical Biology 2009 9:1

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  20. Content type: Research article

    A fundamental goal in chemical biology is the elucidation of on- and off-target effects of drugs and biocides. To this aim chemogenetic screens that quantify drug induced changes in cellular fitness, typically...

    Authors: Jonas Warringer, Dragi Anevski, Beidong Liu and Anders Blomberg

    Citation: BMC Chemical Biology 2008 8:3

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  21. Content type: Research article

    Intracellular free calcium ([Ca2+]i) is a key element in apoptotic signaling and a number of calcium-dependent apoptosis pathways have been described. We here used a chemical biology strategy to elucidate the rel...

    Authors: Maria Hägg Olofsson, Aleksandra Mandic Havelka, Slavica Brnjic, Maria C Shoshan and Stig Linder

    Citation: BMC Chemical Biology 2008 8:2

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  22. Content type: Research article

    Sortin2 is a low mass compound that interferes with vacuolar delivery of proteins in plants and yeast. The Sortin2 phenotype was tested in Arabidopsis thaliana and found to be reversible upon drug removal, demons...

    Authors: Lorena Norambuena, Jan Zouhar, Glenn R Hicks and Natasha V Raikhel

    Citation: BMC Chemical Biology 2008 8:1

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  23. Content type: Research article

    Stimulation of C3H 10T1/2 murine fibroblasts with interferon-γ(IFN) and bacterial lipopolysaccharide (LPS) generates reactive oxygen and nitrogen species leading to DNA damage, lipid oxidation, and tocopherol ...

    Authors: Yuichiro Tanaka, Leslie A Lesoon Wood and Robert V Cooney

    Citation: BMC Chemical Biology 2007 7:2

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